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Combinatorial Chemistry and Molecular Diversity in Drug Discovery by Eric M. Gordon,

Combinatorial Chemistry and Molecular Diversity in Drug Discovery by Eric M. Gordon,
COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY IN DRUG DISCOVERY Edited by Eric M. Gordon and James F. Kerwin, Jr. Increasing pressure to identify, optimize, develop, and commercialize novel drugs more rapidly and more cost-effectively has led to an urgent demand for technologies that can reduce the time to market for new products. Molecular diversity, of both natural and synthetic materials, provides a valuable source of compounds for identifying and optimizing new drug leads. Through the rapidly evolving technology of combinatorial chemistry, it is now possible to produce libraries of small molecules to screen for novel bioactivities. This powerful new technology has begun to help pharmaceutical companies find new drug candidates quickly, save significant dollars in preclinical development costs, and ultimately change their fundamental approach to drug discovery. Comprising the work of the leading authorities in the area of molecular diversity and combinatorial chemistry, Combinatorial Chemistry and Molecular Diversity in Drug Discovery highlights the critical concepts and issues involved in implementing combinatorial chemistry to create chemical libraries. The authors, industrial and academic experts in the field, apply combinatorial technologies to drug discovery and development and place co-evolving technologies and practices in a global framework. Included among the many topics: Historical background. Library strategy and design. Solid-phase synthesis. Small molecular libraries. Automation, analytical, and computational methodology. Biological diversity. Strategies for screening combinatorial libraries. Combinatorial drug screening and development. Combinatorial chemistryinformation management. Combinatorial Chemistry and Molecular Diversity in Drug Discovery is one of the first comprehensive books to cover this explosive area.



The Development Factory: Unlocking the Potential of Process Innovation by Gary P. Pisano,
The Development Factory: Unlocking the Potential of Process Innovation by Gary P. Pisano,
When the pharmaceuticals giant Merck reports promising results for a potential "blockbuster" drug, the story makes the evening news. Now, at a time when new product development has become critical to success in so many industries, The Development Factory proves that process innovation - not just product innovation - can be the key to competitive edge. In this multiyear study of pharmaceutical and biotechnology firms, Gary Pisano explores the dynamics of superior product and process development in a highly competitive industry that lives and dies by its R&D and depends heavily on rapid time to market. His work reveals that behind the success of many new product introductions lies the development of novel process technologies that provide lower costs, higher quality, and increased flexibility. Pisano challenges the widely held product-process life cycle view of competition, which suggests that industries tend to emphasize either product innovation or process innovation. He also questions the notion that there is a conflict between pursuit of product innovation and pursuit of lower costs, arguing that product development and process development capabilities are complementary. Extending the lessons to a wide variety of manufacturing industries, The Development Factory will guide companies toward unlocking the potential of process development and understanding the patterns of organizational behavior and managerial actions that help create and implement new capabilities over time.



Intravenous drug - An intravenous drug (IV drug) is a drug administered intravenously, either by an intravenous drip or a syringe. As it is one of the most effective methods of administering drugs with rapid effect, it is used widely used in medical practice and by recreational drug users.

Federal Food, Drug, and Cosmetic Act - The United States Federal Food, Drug, and Cosmetic Act (FD&C) is a set of laws passed by Congress in 1938 giving authority to the Food and Drug Administration to oversee the safety of food, drugs, and cosmetics. In 1968, the Electronic Product Radiation Control provisions were added to the FD&C.

Drug Identification Number - Any product defined as a drug under the Canadian Food and Drugs Act need to have an associated drug identification number (or DIN).

Drug paraphernalia - Drug paraphernalia is any legitimate equipment, product, or material that is modified for making, using, or concealing illegal drugs such as cocaine, heroin, marijuana, and methamphetamine. Drug paraphernalia generally falls into two categories:



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